Topic: DETERMINE THE ASSOCIATION BETWEEN PDL-1 AND BRCA1 MUTATION IN TRIPLE NEGATIVE BREAST CANCER IN SAUDI POPULATION TO SELECT PATIENTS FOR EFFECTIVE THERAPY TO BECOME THE NEW APPROACH FOR TARGETED THERAPY

BRCA 1 Description

BRCA gene

M‌‍‍‍‌‍‍‍‍‌‍‍‌‌‌‌‍‍‍‌y proposal is about ” DETERMINE THE ASSOCIATION BETWEEN PDL-1 AND BRCA 1 MUTATION IN TRIPLE NEGATIVE BREAST CANCER PATIENTS IN SAUDI POPULATION TO SELECT PATIENTS FOR EFFECTIVE THERAPY TO BECOME THE NEW APPROACH FOR TARGETED THERAPY” Aim: 1. Firstly determine the association between the expression levels of PDL-1 on TNBC selected cases and BRCA 1 mutation 2. Study BRCA 1 mutation variants on the TNBC selected cases 3. Determine the association between p53, pdl-1, and BROCA1 mutation on TNBC I want to write the proposal covering the below points: 1. First background about TNBC treatments (PDL-1,P53 and BRCA1), and responses level for each one in TNBC patients 2. Second the role of using molecular genetics profile for selection patients for treatments

Key points

3. ‌‍‍‍‌‍‍‍‍‌‍‍‌‌‌‌‍‍‍‌Thirdly recovery percentage in TNBC using taxanes to treat P53 mutation for BROCA 1 4. Also recovery percentage in TNBC using ……?……. To treat BROCA 1 mutation 5. Finally variants in TNBC patients who have BRCA1 mutation and its association with high level of PDL-1 expression I have attached a draft that is not completed and need to be paraphrased as all of it copy pasted from internet. Please read all notes in the attached file and write about all mentioned points. Please do not hesitate to contact me in case of any clarification. You can rewrite the research question on BRCA to be more academic without changing the meaning and main objects. Finally please please do not accept my order if you are not specialised in the field. use file with 15 March 2021 title , the other is ol‌‍‍‍‌‍‍‍‍‌‍‍‌‌‌‌‍‍‍‌d version.

Attached Files

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